**Multiple established NFL running backs enter Week 1 with comparable workloads and goal-line roles, producing the tight clustering of implied probabilities around 17–26% for players such as James Cook III, Bijan Robinson, Jonathan Taylor, Jahmyr Gibbs, Derrick Henry, and Saquon Barkley.** Each team’s Week 1 script, red-zone efficiency, and defensive matchup will determine rushing touchdown distribution in a single-game sample, where variance is high and no back holds a decisive edge. Recent 2025 production, updated depth charts, and offensive scheme continuity support broad expectations for volume leaders, yet official injury reports and final lineups remain fluid heading into Sunday’s slate. Trader consensus in the prediction market therefore prices the outcome as highly competitive, with realistic paths for several backs to finish atop the rushing touchdown leaderboard depending on how early games unfold.