Inter Milan enter the 2026-27 Serie A campaign as clear frontrunners for another top-four finish after winning the 2025-26 Scudetto by 11 points under Cristian Chivu, bolstered by additions like John Stones, Djed Spence, and Curtis Jones to an already potent attack that scored 89 goals. Roma, Como, and Juventus stand out among the main challengers following strong prior campaigns and targeted reinforcements—Paulo Dybala’s extension and Donyell Malen at Roma, Nico Paz retention at Como under Cesc Fàbregas, and Kerim Alajbegovic plus Randal Kolo Muani’s return at Juventus with Luciano Spalletti. Napoli under Massimiliano Allegri and AC Milan with Rúben Amorim plus major signings such as Gonçalo Ramos also feature in projections, while Atalanta and Fiorentina provide further depth. The opening weekend results and Opta simulations highlight a competitive group where squad health, European schedules, and mid-season form will shape the final top-four outcomes.